|Died||3979 or later|
|First Appearance||Flames of Doom|
|Last Appearance||Battle of the Titans|
Doctor Zaius reappeared yet again in the animated series, with no obvious connection to any other version of Zaius.
He served as a government official who held influence within the Ape Senate, and had authority over both Cornelius and Zira, and their scientific enterprises, as well as General Urko and his military. He wanted Bill Hudson captured but also distrusted Urko's ambitions.
- The character of Zaius is based on Zaius from Planet of the Apes and Beneath the Planet of the Apes, and on Zaius from the TV Series.